Anesthetic Influences Outcomes of the Chronic Angiotensin II Infusion Model in Mice
نویسندگان
چکیده
منابع مشابه
Tubuloglomerular feedback is decreased in COX-1 knockout mice after chronic angiotensin II infusion.
Prostaglandins (PGs), produced by two isoforms of cyclooxygenase (COX), COX-1 and COX-2, are important modulators of renal hemodynamics. COX-1 and COX-2 are expressed in the kidney often at distinct sites. Thromboxane (TxA(2)), PGE(2), and prostacyclin (PGI(2)) are the major PGs in the renal cortex of mice. Acute infusion of the vasoconstrictor ANG II increases COX-2-dependent PGE(2) and PGI(2)...
متن کاملEditorial Commentary Angiotensin II Infusion Model of Hypertension
There has been a long-standing interest in the possibility that activation of the sympathetic nervous system may contribute to the hypertension induced by angiotensin II (Ang II). This hypothesis is commonly assessed by chronically infusing Ang II and using various tests to determine the sympathetic component to the increase in arterial pressure. Despite a multitude of studies, it is still uncl...
متن کاملIntrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice.
The objectives of this study were to determine the effects of chronic angiotensin II (ANG II) infusions on ANG II content and angiotensinogen expression in the mouse kidney and the role of the angiotensin II type 1 receptor (AT(1)R) in mediating these changes. C57BL/6J male mice were subjected to ANG II infusions at doses of 400 or 1,000 ng.kg(-1).min(-1) either alone or with an AT(1)R blocker ...
متن کاملAngiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension.
The role of the angiotensin II type 2 receptor (AT2R) in cardiovascular physiology remains elusive. We have developed an in vivo lentiviral vector-mediated gene transfer system to study the physiological functions of the AT2R. Our objectives in this study were to determine whether the AT2R influences cardiac hypertrophy and myocardial and perivascular fibrosis in a nongenetic rat model of hyper...
متن کاملBlockade of NF-kappaB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II.
OBJECTIVE Nuclear factor (NF)-kappaB is a key transcription factor that regulates inflammatory processes. In the present study, we assessed the hypothesis that blockade of NF-kappaB may ameliorate ventricular hypertrophy in response to chronic infusion of angiotensin II. METHODS Mice with targeted disruption of the p50 subunit of NF-kappaB (KO) were used to block the activation of NF-kappaB. ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.lb540